DNA testing for health risks and low level inflammation

Aging is a fascinating and complex process. While we all age, we don’t age in the same way. Some individuals maintain vitality and health well into their later years, while others develop age-related conditions earlier in life. Why? The reason lies in the delicate interplay of three main factors: our genes, our environment, and our lifestyle.

Research indicates that approximately 20% of our life expectancy is influenced by our genetic makeup. [1] This means that by understanding our genetic predispositions precisely, we can significantly influence our aging process. By aligning our lifestyle choices with our genetic risks and taking targeted preventive measures, we can actively shape how we age.

Particularly intriguing are small genetic variations called SNPs (Single Nucleotide Polymorphisms). These act like genetic switches, influencing various processes in our bodies that are central to aging.

Small genetic variants can play a role in determining how efficiently our body processes nutrients, protects itself against oxidative stress, and manages inflammation. These processes are fundamental to how we age. The more we understand our unique genetic makeup, the better equipped we are to counter potential weaknesses, improve our health, and optimize our longevity.

Decode the code of aging with DNA testing for diseases

The simplest way to gain insight into your genome is through a DNA risk analysis—a genetic test focusing on genetic variations—followed by personalized professional consultation. Such a DNA test can shed light on key processes, including:

• Methylation: A fundamental process for DNA repair and gene regulation
• Inflammatory Responses: Considered "silent drivers" of aging.
• Oxidative Stress: Can lead to cellular damage.
• Detoxification Mechanisms: Responsible for removing toxins from the body.
• Insulin Sensitivity: Governing energy metabolism.
• Lipid Metabolism: Essential for cellular and vascular health.
• Bone health and vitamin deficiencies 

At AYUN, we offer this DNA risk analysis as part of our Extended and Complete Longevity Check-ups. These tests provide valuable insights into your personal genetic variations, allowing us to tailor your preventive measures and lifestyle adjustments to your genetic profile – with the help of our individual consultations. The earlier you begin these personalized interventions, the greater the positive impact you can have on your aging journey. But it’s never too late to start!

What are SNPs and how do they influence your aging? 

Humans share more than 99% of their genetic material, however, the missing 1% is what makes each of us different. In genetics, these differences are called SNPs (Single Nucleotide Polymorphisms).

These genetic variations can influence how your body ages and responds to lifestyle factors. For example, they may affect how well your body processes nutrients or handles stress. Modern genetic testing allows us to precisely identify these variations—a tremendous advancement that allows almost everyone to gain deep insights into the connections between their genes and health.

In recent years, science has learned more about how these genetic variations specifically influence our aging. For example, it is known that certain gene variations are associated with higher life expectancy. Scientists suspect, for instance, that a specific SNP variation in the ApoE gene, which is involved in fat and cholesterol metabolism, may be linked to increased longevity. [2]

What makes these genetic variations special: They can provide important clues about where your body might need extra support. If we know certain variations affect your metabolism, we can tailor your nutrition and lifestyle accordingly.

Methylation

Methylation is a biochemical process that plays a central role in DNA repair, detoxification, and the production of important neurotransmitters for your brain.

A particularly important gene in this process is MTHFR. Current studies indicate that certain SNP variations in this gene may be associated with cardiovascular disease risk. [3] The reason: MTHFR is crucial for homocysteine metabolism in your body. Elevated homocysteine levels may contribute to the development of heart disease—a significant factor in the aging process.

If DNA testing reveals that you carry a corresponding MTHFR variation, you can counteract its effects through specific dietary changes and supplements.

Chronic inflammation

Inflammation is an important protective mechanism of your body, essential for regeneration and healing. However, when inflammation doesn't resolve on its own, it can become chronic. Chronic inflammation can smolder in the body undetected for a long time, accelerating the aging process, which is why it is often referred to as “inflamm-aging.”

One of the genes involved in regulating inflammatory responses is TNF-alpha (TNFA). Researchers discovered that individuals with a certain variant of this inflammation gene may show higher levels of the inflammatory marker CRP. This variant is also associated with shorter telomeres—the protective end caps of your chromosomes, which are considered an important marker of biological aging. [4]

If you carry this genetic variant, you should pay special attention to your inflammation levels and consider measures such as dietary changes or anti-inflammatory medications.

Oxidative stress

Your cells constantly produce reactive oxygen compounds known as free radicals. These molecules can damage your cells—a process we refer to as oxidative stress. Your body possesses various defense mechanisms to protect against this.

A particularly important enzyme in this process is glutathione peroxidase 1 (GPx1). Specific genetic variations (SNPs) in the GPx1 gene can limit your body’s ability to neutralize free radicals. This can lead to cell damage and accelerate the aging process. The same applies to variations in the SOD2 gene, another important component of your antioxidant defense system. [5] Knowing this, you can pay attention to the amount of antioxidants you can take in nutrition or add antioxidant supplements as part of your healthy habits. 

Insulin sensitivity 

How your body processes sugar is another crucial factor for healthy aging. One significant risk to consider is the development of type 2 diabetes (T2D) over the course of your life—a complex disease caused by a combination of genetic and environmental factors. A DNA test can reveal whether you have a genetic predisposition to developing diabetes—or if you may be particularly protected against it.

For example, individuals carrying a specific variation of the PPARG gene (known as the "G" or Ala12 variant) have shown a significantly lower risk of developing type 2 diabetes. Interestingly, this protective effect appears stronger in people from Northern Europe compared to those from Central and Southern Europe. [6]

Lipid metabolism

Oxidized LDL cholesterol is considered one of the primary risk factors for cardiovascular diseases as we age. The enzyme Paraoxonase 1, produced by the PON1 gene, plays a central role in regulating this "harmful" cholesterol. Recent studies have found that individuals with a specific SNP variant of the PON1 gene show higher levels of oxidized LDL cholesterol (Ox-LDL). [7] The same gene variant is also associated with elevated levels of:

• Triglycerides
• Total cholesterol
• LDL cholesterol

If this variant is identified in a genetic test, a personalized plan can be developed to target your specific lipid profile, actively reducing your risk for cardiovascular diseases.

DNA testing for your health risks at AYUN

Discovering your DNA variants and learning more about your genetic blueprint is fascinating, engaging, and preventive all at once. At AYUN, DNA risk testing for SNP variants is part of our Extended and Complete Longevity Check-ups. These comprehensive evaluations combine genetic test results with additional essential health data. By analyzing your blood biomarkers and physiological metrics, we create a multidimensional picture of your health.

The interplay of all these factors provides a complete understanding of your biological state and identifies concrete opportunities for improvement. Using the insights from your Longevity Check-up, we work with you to develop customized strategies for healthy aging.

From knowledge to action: your personalized prevention strategy

The AYUN Longevity Check-up not only provides insights into your genes but also serves as the foundation for an active and personalized prevention approach. Based on your unique profile, we develop targeted interventions, including:

For methylation:

• Targeted supplementation with methylfolate for specific MTHFR variants
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For inflammation control:

• Omega-3 fatty acids
• HBOT (Hyperbaric Oxygen Therapy)
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For oxidative stress:

• Antioxidant support
• Red light therapy for cell regeneration
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For detoxification:

• Nutritional strategies to enhance detoxification
• Adjustments to environmental factors
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For metabolism and lipid profile:

• Personalized nutrition plans
• IHHT
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At AYUN, we continuously adapt these interventions. Regular check-ups allow us to monitor the effectiveness of your measures and adjust your strategies as needed.

Ready to learn more about your genetic aging profile? Book your Longevity Check-up at AYUN today!

Book your Longevity Check-up now!
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